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Dupre Lyles Little

The person at the center of this case

Dupre Lyles Little

Case
#1466
SourceNamus MissingUpdated May 19, 2026
Anderson County Sheriff's Office
Missing Person ยท Open
5 years waiting ยท since 2021

Missing Person: Dupre Lyles Little

Justice for Dupre Lyles Little โ€” the trail went cold in 2021, but the truth hasn't.

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Key leads to think about

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person
Lead #1

Why did a 63-year-old man leave his residence on foot and where was he headed?

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witness
Lead #2

Were there any witnesses who saw Dupre after he left his residence that day?

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clue
Lead #3

What was his mental and physical state at the time of disappearance, and did he have any medical conditions that might affect his safety?

Dupre Lyles Little, a 63-year-old man, disappeared from his residence in Seneca, South Carolina on September 18, 2021, after leaving on foot. Despite the passage of time, his whereabouts remain unknown and the circumstances surrounding his disappearance are unclear. Anyone with information about his location or activities that day is urged to contact the Anderson County Sheriff's Office.

Case
#1466
SourceNamus MissingUpdated May 19, 2026
Anderson County Sheriff's Office

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Official wording

Source Narrative

NamUs case MP102350. Missing person: Dupre Lyles Little.

Last known contact: 2021-09-18 in Seneca, Anderson, SC. Circumstances: Last seen at residence and left on foot.

Demographics: 63 years, Male, White / Caucasian. Physical description: 5 ft 7 in, 120 lbs, hair: Gray or Partially Gray, eyes: Brown.

Investigating agency: Anderson County Sheriff's Office | 2021-36465 | 2021-09-19.

Timeline of Events

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2021-09-18

Last seen at residence

Dupre Lyles Little was last seen at his residence in Seneca, Anderson, SC and left on foot.

Key Locations
Interactive map showing important locations related to this case

Case Information

Incident:September 18, 2021
Last Updated:September 26, 2026

Have Information?

Any information, no matter how small, could be crucial to solving this case.

Phone: 8642604400
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Case Information

Incident:September 18, 2021
Last Updated:September 26, 2026

Have Information?

Any information, no matter how small, could be crucial to solving this case.

Phone: 8642604400
You can remain anonymous