The person at the center of this case
Dupre Lyles Little
Missing Person · Open
4 years waiting · since 2021
Missing Person: Dupre Lyles Little
Justice for Dupre Lyles Little — the trail went cold in 2021, but the truth hasn't.
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Key leads to think about
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location
Lead #1Why did he leave his residence on foot, and where was he headed?
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timeline
Lead #2Has anyone reported seeing him in the days or weeks following his disappearance?
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person
Lead #3Were there any health concerns, financial troubles, or personal circumstances that may have prompted him to leave?
Dupre Lyles Little, a 63-year-old man, went missing on September 18, 2021, after leaving his residence on foot in Seneca, South Carolina. Nearly five years later, his whereabouts remain unknown despite investigation by the Anderson County Sheriff's Office. Anyone with information about his disappearance is urged to contact authorities immediately.
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Official wording
Source Narrative
NamUs case MP102350. Missing person: Dupre Lyles Little.
Last known contact: 2021-09-18 in Seneca, Anderson, SC. Circumstances: Last seen at residence and left on foot.
Demographics: 63 years, Male, White / Caucasian. Physical description: 5 ft 7 in, 120 lbs, hair: Gray or Partially Gray, eyes: Brown.
Investigating agency: Anderson County Sheriff's Office | 2021-36465 | 2021-09-19.
Timeline of Events
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2021-09-18
Last Known Contact
Dupre Lyles Little was last seen at his residence in Seneca, Anderson, SC and left on foot.
Key Locations
Interactive map showing important locations related to this case
Case Information
Incident:September 18, 2021
Last Updated:May 29, 2026
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Any information, no matter how small, could be crucial to solving this case.
Phone: 8642604400
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Case Information
Incident:September 18, 2021
Last Updated:May 29, 2026
Have Information?
Any information, no matter how small, could be crucial to solving this case.
Phone: 8642604400
You can remain anonymous