The person at the center of this case
Dupre Lyles Little
Missing Person · Open
4 years waiting · since 2021
Missing Person: Dupre Lyles Little
Justice for Dupre Lyles Little — the trail went cold in 2021, but the truth hasn't.
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Key leads to think about
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witness
Lead #1Were there any witnesses who saw Dupre Lyles Little on or after September 18, 2021, in the Seneca area?
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location
Lead #2Where might a 63-year-old man on foot travel from his residence, and are there areas of concern such as bodies of water or remote locations nearby?
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clue
Lead #3Has any evidence, clothing, or personal items belonging to Dupre Lyles Little been found in the surrounding area?
Dupre Lyles Little, a 63-year-old male, went missing on September 18, 2021, after leaving his residence on foot in Seneca, South Carolina. Nearly five years later, his whereabouts remain unknown, and investigators have not determined what happened to him. Anyone with information about his disappearance is urged to contact the Anderson County Sheriff's Office.
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Official wording
Source Narrative
NamUs case MP102350. Missing person: Dupre Lyles Little.
Last known contact: 2021-09-18 in Seneca, Anderson, SC. Circumstances: Last seen at residence and left on foot.
Demographics: 63 years, Male, White / Caucasian. Physical description: 5 ft 7 in, 120 lbs, hair: Gray or Partially Gray, eyes: Brown.
Investigating agency: Anderson County Sheriff's Office | 2021-36465 | 2021-09-19.
Timeline of Events
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2021-09-18
Last Known Contact
Dupre Lyles Little was last seen at his residence in Seneca, Anderson, SC. He left on foot and has not been located.
Key Locations
Interactive map showing important locations related to this case
Case Information
Incident:September 18, 2021
Last Updated:May 20, 2026
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Any information, no matter how small, could be crucial to solving this case.
Phone: 8642604400
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Case Information
Incident:September 18, 2021
Last Updated:May 20, 2026
Have Information?
Any information, no matter how small, could be crucial to solving this case.
Phone: 8642604400
You can remain anonymous